Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits.
Title | Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Taleban S, Li D, Targan SR, Ippoliti A, Brant SR, Cho JH, Duerr RH, Rioux JD, Silverberg MS, Vasiliauskas EA, Rotter JI, Haritunians T, Shih DQ, Dubinsky M, Melmed GY, McGovern DPB |
Journal | J Crohns Colitis |
Date Published | 08/2015 |
Abstract | Background: There has been considerable progress in identifying inflammatory bowel disease [IBD] susceptibility genes but little progress in examining the role of genetic variation in the development of the extra-intestinal manifestations [EIMs] of IBD. This study identified clinical, serological, and genetic factors associated with ocular EIMs [O-EIMs] in IBD. Methods: We performed a retrospective case-control study of IBD patients, comparing those with and without O-EIMs using the Cedars-Sinai IBD Research Repository and the NIDDK IBD Genetics Consortium Repository. Genotyping was performed using Illumina whole genome platforms. Results: In all, 124 cases and 3328 controls with available clinical data were identified; 103 cases and 2808 controls had genetic data available. Erythema nodosum and peripheral arthritis particularly were common in patients with O-EIMs [p = 2.77 x 10(-13) and p = 2.58 x 10(-13), respectively] with increasing odds ratios for O-EIMs with each additional non-ocular-EIM [for ≥ 2 EIMs, odds ratio 14.72]. Nominal association with O-EIMs was observed at several known IBD susceptibility single nuclear polymorphisms. One locus, containing RBM19, achieved genome-wide level of significance for association with O-EIMs. Conclusions: In IBD, O-EIMs co-occur with musculoskeletal and skin manifestations and, in this study, are nominally associated with known IBD loci. Additional cohorts are needed to verify these results and identify additional genes. |
DOI | 10.1093/ecco-jcc/jjv178 |
PubMed ID | 26449790 |
PubMed Central ID | PMC6082592 |
Grant List | U01 DK062432 / DK / NIDDK NIH HHS / United States U01 DK062429 / DK / NIDDK NIH HHS / United States DK62429 / DK / NIDDK NIH HHS / United States U01 DK062422 / DK / NIDDK NIH HHS / United States DK62422 / DK / NIDDK NIH HHS / United States DK062431 / DK / NIDDK NIH HHS / United States DK062420 / DK / NIDDK NIH HHS / United States U01 DK062423 / DK / NIDDK NIH HHS / United States DK046763 / DK / NIDDK NIH HHS / United States U01 DK062420 / DK / NIDDK NIH HHS / United States U01 DK062431 / DK / NIDDK NIH HHS / United States |