Inflammatory bowel disease and the elderly: a review.
Title | Inflammatory bowel disease and the elderly: a review. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Taleban S, Colombel J-F, M Mohler J, Fain M |
Journal | J Crohns Colitis |
Volume | 9 |
Date Published | 06/2015 |
Abstract | Inflammatory bowel disease among the elderly is common, with growing incident and prevalence rates. Compared with younger IBD patients, genetics contribute less to the pathogenesis of older-onset IBD, with dysbiosis and dysregulation of the immune system playing a more significant role. Diagnosis may be difficult in older individuals, as multiple other common diseases can mimic IBD in this population. The clinical manifestations in older-onset IBD are distinct, and patients tend to have less of a disease trajectory. Despite multiple effective medical and surgical treatment strategies for adults with Crohn's disease and ulcerative colitis, efficacy studies typically have excluded older subjects. A rapidly ageing population and increasing rates of Crohn's and ulcerative colitis make the paucity of data in older adults with IBD an increasingly important clinical issue. |
DOI | 10.1093/ecco-jcc/jjv059 |
PubMed ID | 25870198 |